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While the niacinamide form of vitamin B3 doesn’t reduce cholesterol levels or cause the red flush of the skin like its B3 cousin, niacin does, it still has many unique functional benefits. It’s required for hundreds of enzymatic reactions in the body. It is vital nutritional support for those with osteoarthritis, rheumatoid arthritis, diabetes, asthma, heart disease, stress and stroke.
About 2/3 of your body’s niacinamide is made from the amino acid, tryptophan. Some people supplement niacinamide to fill this pathway and force tryptophan down the serotonin pathway, boosting serotonin levels.
Niacinamide becomes part of two related oxidation reduction coenzymes NAD (nicotinamide adenine dinucleotide and its close cousin NADP (nicotinamide adenine dinucleotide phosphate). These coenzymes transport the vital hydride ion as NADH and NADPH respectively. The output of the glycolytic and Kreb’s cycle in the mitochondria is NADH which then forms 3ATPs. This is important because without ATP, our cellular battery, we would need to eat constantly, if we fell asleep, we’d die.
Possibly the most exciting benefit of niacinamide is its anti-aging effects. Research has revealed a longevity gene known as Sir2 (silent information regulator 2) that produces the protein Sir2p that has been shown to extend cell life. Niacinamide enhances Sir2p activity by increasing NAD. (For more on Sir2 and Sir2p, look at our new Extension Resveratrol formula and its related articles.)
Niacinamide helps control osteoarthritis inflammation by mediating Interleukin I (IL-1) and by inhibiting the Nitric Oxide (NO) free radical. In Type 1 diabetics, niacinamide helps regenerate pancreatic function by slowing beta cell death. These are the insulin producing cells of the pancreas. Type 2 diabetics notice reduced glycosylated hemoglobin (A1C) levels as a result of better glycemic control.
Niacinamide is an inexpensive nutrient that is both safe and effective with a multitude of uses in optimizing physiology and controlling pathology.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.